Role for a bidentate ribonuclease in the initiation step of RNA interference

By Emily Bernstein, Amy A. Caudy, Scott M. Hammond, Gregory J. Hannon. Nature, 2001

932 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/e62d0f9b212e8648632a1dacc8a8839686114c8d

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Citations in the corpus

Genetic transformation technology: Status and problems (2005, background): “In PTGS, dsRNA is reported to act as a trigger for sequencespecific RNA degradation (Bass, 2000; Zamore et al., 2000; Bernstein et al., 2001).”
Development of microRNA therapeutics is coming of age (2014, neutral): “…70 nt pre-miRNA hairpin structures and then in the cytoplasm by the Dicer – TRBP complex to approximately 22 nt miRNA duplexes (Fig 1) (Bernstein et al , 2001; Grishok et al , 2001; Hutva´gner et al , 2001; Lee et al , 2003, 2004; Yi et al , 2003; Bohnsack et al , 2004; Denli et al ,…”
ATP requirements and small interfering RNA structure in the RNA interference pathway. (2001, neutral): “of ATP (Figure 2 ) and incubated at room temperature cleavage of the dsRNA into siRNAs requires ATP (Zafor 30 min, and then a Rr-luc target mRNA was added. more et al., 2000; Bernstein et al., 2001).”
Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants (2011, neutral): “Their primary transcripts form precursor RNAs, which have a partially double-stranded stem-loop structure and which are processed by DCL proteins to release mature miRNAs [26].”
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. (2005, background): “RNA interference (RNAi) begins with the production of w21 nt, double-stranded RNAs called small interfering RNAs (siRNAs; Hamilton and Baulcombe, 1999; Hammond et al., 2000; Zamore et al., 2000; Elbashir et al., 2001a, 2001b; Bernstein et al., 2001 ).”
Small silencing RNAs: an expanding universe (2009, neutral): “In these cases, long exogenous dsRNA is cleaved into double-stranded siRNAs by Dicer, a dsRNA-specific RNase III family ribonucleas”
Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. (2005, background): “Moreover, we showed previously (Chendrimada et al., 2005) Previous studies have identified a variety of different proteins as potential components of the RISC, although few of them have been functionally characterized at the molecular level (Caudy et al., 2001).”
Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline. (2001, background): “The presence of endogenous dsRNA in testes suggests that small RNAs that are derived from the dsRNA by endonucleolytic cleavage are being produced [9, 10, 25, 26] .”
microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7 (2010, neutral): “Dicer encodes an RNase III endonuclease responsible for miRNA maturation; therefore, deletion of Dicer leads to depletion of all mature and functional miRNAs (Bernstein et al., 2001; Grishok et al., 2001).”
Computational identification of Drosophila microRNA genes (2003, background): “Processing of pri-miRNA into the premiRNA stem-loop occurs in the nucleus, while subsequent processing of pre-miRNA into 21-22 mers is a cytoplasmic event mediated by the RNAse III enzyme Dicer [17-20]; Dicer is also responsible for cleavage of long perfectly doublestranded RNA into 21-22 nucleotide”
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. (2006, background): “…structure is recognized by a complex containing the RNase Dicer, which processes the pre-miRNA into the mature effector z 22-nt miRNA molecule (Bernstein et al. 2001; Grishok et al. 2001; Hutvagner et al. 2001; Ketting et al. 2001; Chendrimada et al. 2005; Forstemann et al. 2005; Gregory et…”
Two classes of short interfering RNA in RNA silencing (2002, neutral): “74 / -8889/ = $ ) $ !”
MicroRNA targets in Drosophila (2003, neutral): “Both siRNAs and miRNAs are processed from doublestranded RNA precursors requiring dsRNA-specific RNase III enzymes [26-30].”
A combined computational-experimental approach predicts human microRNA targets. (2004, neutral): “2001) from doublestranded RNAs (Bernstein et al. 2001).”