Development of microRNA therapeutics is coming of age
By Eva van Rooij, Sakari Kauppinen. EMBO Molecular Medicine, 2014
624 citations recorded by the source corpus.
MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on the development of miRNA‐based therapeutics for the treatment of cancer, cardiovascular disease and hepatitis C virus (HCV) infection.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8e1199eb02563745b7723af93f5d10589d54b944
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In Cancer Research
In Molecular Biology
Citations in the corpus
- An overview of microRNAs (2015, background): “As miRNAs become causally linked to increasing numbers of human diseases there are expanding efforts to develop therapeutics that directly target the miRNA[234-236].”
- miR-122--a key factor and therapeutic target in liver disease. (2015, neutral): “chemically modified anti-miR oligonucleotides [123].”