microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7

By Jian-Fu Chen, Yazhong Tao, Juan Li, Zhongliang Deng, Zhen Yan, Xiaolong Xiao, Da-Zhi Wang. Journal of Cell Biology, 2010

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Pax7 is a target of two miRNAs that are induced during muscle satellite cell differentiation and repressed in response to muscle injury.

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Satellite cells and the muscle stem cell niche. (2013, background): “These myogenic microRNAs, in conjunction with other microRNAs, modulate the expression levels of key myogenic transcription factors and regulators, such as Pax3 (119, 196, 231), Pax7 (94, 139), SRF (93), c-Met (526, 577), and Dek (98) during satellite cell activation/proliferation and differentiatio”
What determines growth potential and juvenile quality of farmed fish species (2013, background): “Several miRNAs are known to regulate muscle growth; for example, miR-1 and miR-206 promote satellite cell differentiation in mice by restricting their proliferative potential through downregulation of Pax7 (Chen et al. 2010).”
Building muscle: molecular regulation of myogenesis. (2012, background): “Through this miR206-mediated negative feedback mechanism, MyoD facilitates progression toward terminal differentiation (Chen et al. 2010; Hirai et al. 2010).”
Satellite Cells and Skeletal Muscle Regeneration (2015, unknown): “These microRNAs enhance differentiation by directly inhibiting Pax7 transcription, which consequently results in increased MyoD activity (57,87).”