Aβ Oligomers – a decade of discovery

By D. Walsh, D. Selkoe. Journal of Neurochemistry, 2007

2,034 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/e49f393fa84fb699032998a4c91d39e7fdcf9087

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. P. Reddy
2. Fred H. Gage
3. P. Mao
4. R. Swerdlow
5. M. Calkins
6. U. Shirendeb
7. M. Mańczak
8. Shaharyar M. Khan

In Pharmacology

1. P. Reddy
2. E. Masliah
3. Xia Zhang
4. Wei-Wei Chen
5. Fred H. Gage
6. Suzanne L. Baker
7. Michael W. Weiner
8. Gil D. Rabinovici

In Physiology

1. J. Burns
2. M. Calkins
3. R. Swerdlow
4. M. Mańczak
5. P. Reddy
6. Shaharyar M. Khan
7. E. Masliah
8. C. Duyckaerts

Citations in the corpus

• Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. (2009, background): “Soluble species are considered the most toxic form of Ab, and have been shown to correlate with synapse loss and disease severity better than Ab plaques (Walsh and Selkoe, 2007).”
• Role of oxidative stress in Alzheimer's disease (2016, background): “This seems to be associated with the length of Aβ fragments, with Aβ (1-42) being more toxic than Aβ (1-40) and the most likely candidate to generate hydrogen peroxide and other ROS (54).”
• Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020, background): “Extracellular Aβ aggregates in their fibrillar form are resistant to hydrolytic degradation [52, 53].”
• Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease (2017, background): “A popular line of AD research argues A , and perhaps specifically oligomeric conformations of a 42 amino acid-long A species, initiates neurodegeneration [24, 25].”
• National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease (2012, positive): “Further, Ab peptides are diverse proteins with heterogeneous lengths, amino- and carboxyl-termini, posttranslational modifications, and assembly states that span from small oligomers and protofibrils to fibrils with the physicochemical properties of amyloid [33].”
• The Alzheimer's Disease Mitochondrial Cascade Hypothesis: Progress and Perspectives (2013, background): “Initial versions claimed plaque Aβ caused AD; current versions claim Aβ oligomers cause AD [17].”