Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.

By E. Mormino, J. Kluth, Cindee M. Madison, Gil D. Rabinovici, Suzanne L. Baker, B. Miller, Robert A. Koeppe, C. Mathis, Michael W. Weiner, W. Jagust. Brain : a journal of neurology, 2009

695 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Physiology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/57f94deb144de665602d0d7adcdfe5ee8e14f099

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Citations in the corpus

PET Imaging of Tau Deposition in the Aging Human Brain (2016, positive): “T1 MPRAGE scans were processed as described previously using FreeSurfer version 5.1 (http://surfer.nmr.mgh.harvard.edu/) (Mormino et al., 2009).”
Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria (2016, background): “Across studies, those individuals showing abnormalities in both Ab and additional biomarkers that demonstrate more rapid cognitive decline and higher rates of conversion to prodromal and/or dementia, whereas individuals with an isolated abnormality in Ab show marginal or no difference from Ab-negati”
The Episodic Memory System: Neurocircuitry and Disorders (2009, neutral): “…have begun to combine these various imaging modalities to highlight the important observation that the molecular pathology of AD is localized in and is associated with dysfunction and atrophy of brain areas that include the episodic memory network (Buckner et al, 2005; Mormino et al, 2009).”
The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception (2011, neutral): “Mormino et al [206] investigated the relationship between Ab deposition, as measured by 11C-PiB PET uptake, hippocampal atrophy, and episodic memory loss in cognitively normal healthy elderly subjects.”
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease (2009, neutral): “Alzheimer’s disease patients met published criteria for probable Alzheimer’s disease (McKhann et al ., 1984) with MMSE scores of 20–26 and CDR scores of 0.5–1.0.”
What is normal in normal aging? Effects of Aging, Amyloid and Alzheimer’s Disease on the Cerebral Cortex and the Hippocampus (2014, background): “Correlations between Ab and hippocampal volume (Mormino et al., 2009; Arenaza-Urquijo et al., 2013b) or atrophy (Fjell et al., 2010a) have been observed, but when compared to correlations with other subcortical structures, Ab-atrophy relationships often do not stand out as especially strong (Fjell…”