A combined chemical and genetic approach for the generation of induced pluripotent stem cells.

By Yan Shi, J. Do, C. Desponts, H. S. Hahm, Hans Robert Schöler, Sheng Ding. Cell Stem Cell, 2008

709 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e48505fed68fcb113341ed3decb2bf2c6238de42

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Citations in the corpus

Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “In a chemical compound screen, an inhibitor of G9a histone methyltransferase BIX-01294 was found to improve reprogramming of mouse neural progenitor cells transduced with Oct4 and Klf4 (8- fold)(Shi et al., 2008b).”
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. (2008, background): “It is therefore fitting that we previously observed that BIX can facilitate the generation of iPSCs from NPCs transduced with either OK or Klf4/Sox2/c-Myc (Shi et al., 2008), suggesting that it can compensate for the exogenous expression of Sox2 or Oct4.”
Risk factors in the development of stem cell therapy (2011, methodology): “These methods are based on the endogenous activation of reprogramming factors as was reported for the reactivation of the Oct3/4 gene [79,80].”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “It is interesting to note that Nanog expression also appears to be a limiting factor during fusion-mediated reprogramming (Silva et al. 2006), suggesting common mechanisms.”
Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014) (2014, background): “Potentially risky viral integration of transcription factors were replaced with the use of neural progenitor cells and small molecules [18] or ‘piggyBac’ transposition [19].”
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 (2008, background): “Mouse neural stem cells that express endogenous Sox2 can be reprogrammed to a pluripotent state with the addition of only two transcription factor”
A fresh look at iPS cells. (2009, background): “Several groups have already identified chemicals that can replace one or two reprogramming factors during iPS cell generation (Huangfu et al., 2008; Shi et al., 2008).”
Epigenetic reprogramming and induced pluripotency (2009, background): “…are implicated in the silencing of Oct4 and other pluripotency genes – histone deacetylation, histone methylation and DNA methylation – improves the efficiency of transcription factorinduced reprogramming (Huangfu et al., 2008a; Huangfu et al., 2008b; Mikkelsen et al., 2008; Shi et al., 2008b).”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “Screens to replace the reprogramming factors in the mouse and in the human system have led to the replacement of single factors (Huangfu et al., 2008; Shi et al., 2008a, 2008b).”
Pioneer transcription factors: establishing competence for gene expression. (2011, background): “A role for an epigenetic component is supported by the ability of inhibitors of histone-modifying enzymes to enhance reprogramming (Huangfu et al. 2008; Shi et al. 2008).”
Hypoxia enhances the generation of induced pluripotent stem cells. (2009, background): “Recently, small-molecule compounds have been reported to enable the reprogramming of Oct3/4 and Klf4-transduced MEFs to iPS cells (Shi et al., 2008a).”