Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

By Danwei Huangfu, K. Osafune, René Maehr, Wenjun Guo, A. Eijkelenboom, Shuibing Chen, W. Muhlestein, D. Melton. Nature Biotechnology, 2008

1,405 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a579d88935b8832abffc5d79654165a98700459e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Oct4-induced pluripotency in adult neural stem cells. (2009, positive): “, 2007), iPS cells have been generated without infection of the c-Myc oncogene (Huangfu et al., 2008; Nakagawa et al., 2008; Wernig et al., 2008).”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “2010), and human iPSCs in the absence of both SOX2 and C-MYC (Huangfu et al. 2008b).”
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency (2011, neutral): “OSKM-reprogrammed MEFs do show Oct4-GFP expression at both 6 and 8 days of the reprogramming process, with up to 17% of cells expressing GFP by day 8, which is in the same range as previously reported (Figure 3E; Huangfu et al., 2008a).”
Epigenetic reprogramming and induced pluripotency (2009, background): “…are implicated in the silencing of Oct4 and other pluripotency genes – histone deacetylation, histone methylation and DNA methylation – improves the efficiency of transcription factorinduced reprogramming (Huangfu et al., 2008a; Huangfu et al., 2008b; Mikkelsen et al., 2008; Shi et al., 2008b).”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “Screens to replace the reprogramming factors in the mouse and in the human system have led to the replacement of single factors (Huangfu et al., 2008; Shi et al., 2008a, 2008b).”
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon (2009, positive): “The serum-free culture had been previously shown to enhance reprogramming of both mouse and human fibroblast”
A fresh look at iPS cells. (2009, background): “Several groups have already identified chemicals that can replace one or two reprogramming factors during iPS cell generation (Huangfu et al., 2008; Shi et al., 2008).”
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (2011, background): “CD44, stem cell master genes and epigenetics Embryonic stem (ES) cells are characterized by the expression of a set of transcription factor”