Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.

By B. Heissig, K. Hattori, S. Dias, M. Friedrich, B. Ferris, N. Hackett, R. Crystal, P. Besmer, D. Lyden, M. Moore and 2 more. Cell, 2002

1,871 citations recorded by the source corpus.

Subfields: Cancer Research, Hematology

View Paper: https://www.semanticscholar.org/paper/e3aeb35bb1b2b5b493779f9dfe7758a126ae5f83

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In Cancer Research

1. Rakesh K. Jain
2. D. Hanahan
3. Zena Werb
4. Peter Carmeliet
5. P. E. Van den Steen
6. G. Opdenakker
7. J. Vandooren
8. V. Plaks

In Hematology

1. J. Vandooren
2. P. E. Van den Steen
3. G. Opdenakker
4. Zena Werb
5. A. Trumpp
6. Anne Wilson
7. V. Plaks
8. D. Lyden

Citations in the corpus

• Neutrophils and immunity: challenges and opportunities (2006, background): “Stromal-cell-derived G-CSF triggers bone-marrow neutrophils to release matrix metalloproteinase 9 (MMP9), which solubilizes KIT ligand, helping to mobilize progenitor cell”
• Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis (2004, neutral): “We have shown that marrow suppression is accompanied by regression of BMECs followed by rapid regeneratio”
• Molecular mechanisms and clinical applications of angiogenesis (2011, background): “Proteases such as MMP9 also participate in the mobilization of progenitors from the bone marrow by shedding soluble forms of membrane-bound cytokines (such as KIT ligand; also known as stem-cell factor or SCF”
• Matrix Metalloproteinases: Regulators of the Tumor Microenvironment (2010, background): “marrow (Heissig et al., 2002), which may be of particular significance in this context, given that the niche-forming progenitor cells express c-Kit (Kaplan et al.”
• G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4 (2002, background): “—is released from the BM into the blood during mobilization in mic”
• The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. (2007, background): “Direct evidence for the role of SDF-1 in regulating mobilization of pro-angiogenic BM cells in vivo has been demonstrated by plasma elevation of SDF-1, which stimulates mobilization of CXCR4+ BM cells, including HSCs and EPCs [31,32].”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “VEGF, SDF-1, and placenta growth factor (PlGF)-induced stem cell mobilization is dependent on MMP-9 (278), which is required for the cleavage of membrane-bound Kit ligand (278).”
• Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2 mediated regeneration of sinusoidal endothelial cells (2009, neutral): “Although the phenotypic and functional attributes of the OBN are well defined (Arai et al., 2004; Calvi et al., 2003; Hattori et al., 2002; Heissig et al., 2002; Kiel et al., 2005; Yoshihara et al., 2007; Zhang et al., 2003), the identity of the vascular compartments in BM contributing to…”
• Matrix metalloproteinases and tumor metastasis (2006, background): “Importantly, the pre-metastatic clusters express MMP-9 [66], the upregulation of which can serve to break down basement membrane and release VEGF and soluble kit-ligand [67, 68].”