Neutrophils and immunity: challenges and opportunities

By C. Nathan. Nature reviews. Immunology, 2006

3,017 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c5892671cd0ceaff09fe9b8e4254314703552a47

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In Immunology

Citations in the corpus

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality (2011, neutral): “Neutrophils have an essential role in innate immunity and are the first cells recruited to the site of infection.(1) Human neutrophils are the most abundant leukocytes.”
UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies (2017, background): “The last is responsible for spontaneously production of matrix metalloproteinase 9 (MMP9) by neutrophils and their transepithelial movement (Nathan, 2006).”
Dectin-1 is required for β-glucan recognition and control of fungal infection (2006, background): “That occurred in the context of a deficiency in inflammatory mediators and growth factors, which would normally enhance neutrophil activation and neutrophil-mediated killin”
Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans (2009, background): “Microbes engulfed by neutrophils are efficiently killed by reactive oxygen species (ROS) and antimicrobial proteins within vacuoles [2].”
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.”
Origin and physiological roles of inflammation (2008, background): “The neutrophils attempt to kill the invading agents by releasing the toxic contents of their granules, which include reactive oxygen species (ROS) and reactive nitrogen species, proteinase 3, cathepsin G and elastas”
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) (2011, background): “Mice with a null allele of the gene involved in X-linked CGD, gp91phox, which encodes the 91-kD subunit of the burst (Nathan, 2006).”
The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. (2010, neutral): “Neutrophils contribute to the inflammatory response by the release of superoxide and other reactive oxygen species (Nathan, 2006).”
Inflammatory responses and inflammation-associated diseases in organs (2015, background): “Neutrophils, which target microorganisms in the body, can also damage host cells and tissues [74].”
Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury (2011, background): “Neutrophils (polymorphonuclear granulocytes), the first inflammatory leukocytes to invade injured tissue from the circulation, phagocytose debris and modulate recruitment and activation of other leukocytes (mainly monocytes) during Wallerian degeneration [107].”
Tumor-associated neutrophils: new targets for cancer therapy. (2011, background): “Neutrophils, or PMNs, exist to defend the host from invading microorganisms and to assist in wound healing (2).”
Innate immunity in the central nervous system. (2012, neutral): “That neutrophils are considered the first line of defense against extracellular and intracellular bacteria is illustrated by life-threatening conditions that result from neutrophil deficiency (118, 119).”
Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing (2010, background): “This combined with the abrupt release of reactive oxidative species (respiratory burst) can cause further damage to the tissue [ 81 ] .”