G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

By I. Petit, M. Szyper‐Kravitz, A. Nagler, M. Lahav, A. Peled, L. Habler, T. Ponomaryov, R. Taichman, F. Arenzana‐Seisdedos, N. Fujii and 3 more. Nature Immunology, 2002

1,402 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/67a5add92a1504ed38d202cac149c1a12a7a12c5

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In Hematology

1. D. Lyden
2. Zena Werb
3. F. Balkwill
4. P. Frenette
5. J. Talmadge
6. S. Fricker
7. B. Teicher
8. I. J. Fidler

In Immunology

1. Zena Werb
2. F. Balkwill
3. Caroline L. Sokol
4. Christian Weber
5. Jianhua Wang
6. Robert Samstein
7. J. Griffith
8. D. Lyden

In Oncology

1. Zena Werb
2. F. Balkwill
3. Caroline L. Sokol
4. Jianhua Wang
5. D. Hicklin
6. D. Lyden
7. R. Taichman
8. A. Luster

Citations in the corpus

• Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, methodology): “A common method of stem cell mobilization in humans, G-CSF treatment, promotes the destruction of CXCL12 in the bone marrow and the appearance of peripheral blood HSCs with low CXCR4 expression (10).”
• Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells (2006, background): “These are followed by degradation of SDF-1, increased expression of CXCR4 and mobilization of maturing leukocytes, progenitors and stem cell”
• HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. (2003, methodology): “Proteolytic cleavage associated with inactivation of SDF-1 was demonstrated by several degrading enzymes (28, 33, 34) including MMP-2 and MMP-9, which cleave the N-terminus (35).”
• Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. (2002, methodology): “Of interest, neutralizing anti-CXCR4 or anti-SDF- 1 antibodies significantly reduced stem cell mobilization, demonstrating a role for SDF-1/CXCR4 signaling in cell egress as well [ 63 ].”
• Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, methodology): “, CD26, cathepsin G, elastase, MMP2, and MMP9) that degrade CXCL12 (25).”