In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.

By Andreea Ianus, G. Holz, N. Theise, M. Hussain. Journal of Clinical Investigation, 2003

616 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/b57f9ddf02ca508fc01ea51c48279c5af7898309

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In Endocrinology, Diabetes and Metabolism

In Molecular Biology

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Citations in the corpus

β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans (2008, background): “Other investigators have proposed that bone marrow stem cells may give rise to -cells in mice (18), although this has subsequently been challenged in murine and human studies (19,20).”
Growth and regeneration of adult beta cells does not involve specialized progenitors. (2007, background): “Several mechanisms have been invoked to explain adult b cell mass expansion, including neogenesis from pancreatic ducts (Bonner-Weir, 2000) or hematopoietic tissues (Ianus et al., 2003), intraislet replication of highly replicative insulin-positive b cell progenitors (Bonner-Weir, 1992; Swenne, 1983”
Stem cell plasticity: time for a reappraisal? (2005, positive): “The fact that Y, GFP-negative pancreatic cells were found suggests that no fusion had occurred.(31,32) Hess et al.”
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes (2003, methodology): “This method previously failed to detect evidence of cell fusion in the pancrea”
Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. (2006, background): “However, in other experimental systems, the cell fusion process has been excluded as a way to explain bone marrow SC plasticity (44,45).”
Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. (2004, result): “This is, however, a controversial issue, because in other experimental systems—skeletal muscle and pancreatic islets of Langerhans—the cell fusion process has been excluded as a way to explain BM stem cell plasticity (44,45).”