Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

By A. Mangi, N. Noiseux, D. Kong, Huamei He, M. Rezvani, J. Ingwall, V. Dzau. Nature Medicine, 2003

1,558 citations recorded by the source corpus.

Subfields: Biomaterials, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/2ee68dc71131418c53e99e895a96e39ad5ea9834

How researchers see this paper

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In Biomaterials

1. A. Caplan
2. R. Lee
3. J. Karp

In Genetics

1. J. Karp
2. A. Caplan
3. R. Lee
4. C. Gregory
5. Kenneth R. Boheler
6. Victor M. Montori
7. Deepak Srivastava
8. Jeffrey L Spees

In Surgery

1. A. Caplan
2. R. Lee
3. J. Karp
4. C. Gregory
5. Jeffrey L Spees

Citations in the corpus

• Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. (2007, background): “Genetic modifications of BMCs prior to transplantation may also potentially improve their regenerative capability.(44) These avenues may be explored in future trials.”
• Stem cell plasticity: time for a reappraisal? (2005, neutral): “In a very interesting recent study, the injection of marrow cells transduced with the prosurvival gene Akt1 (encoding the Akt protein) into ischemic rat myocardium inhibited cardiac remodeling by reducing intramyocardial inflammation, collagen deposition and cardiac myocyte hypertrophy, and regenera”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, methodology): “VIIIC), but it has been successfully employed in rodent models with a variety of stem cells isolated as primary isolates, following cultivation in vitro or following genetic modification (219, 384).”
• Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy (2005, methodology): “…myocardium and form connections with native cardiomyocytes in rats with DCM. Unlike earlier studies that have used a model of myocardial infarction, 7,9,23 we used a rat model of DCM to demonstrate the engraftment and cardiogenic differentiation of MSCs. Importantly, MSC transplantation improved…”
• Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “Although it is unlikely that bone marrow-derived stem cells differentiate into myocytes, they may fulfill a noncell-autonomous function by secreting paracrine factors that promote survival or neoangiogenesis to protect and rescue the ischemic myocardium (Mangi et al., 2003).”
• Evidence supporting paracrine hypothesis for Akt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement (2006, methodology): “We previously showed that the intramyocardial injection of bone marrow-derived MSCs overexpressing Akt is a superior strategy for rescuing tissue damage caused by acute infarction compared with the administration of control MSCs (20).”
• Mesenchymal stem cells as trophic mediators (2006, background): “Recent studies [Mangi et al., 2003] document the effects of transplantedMSCs expressing the pro-survival gene Akt1, and the authors recognized that the molecules released by transplanted MSCs are important.”
• Spontaneous human adult stem cell transformation. (2005, background): “for tissue regeneration and engineering (17, 18), due to their plasticity, easy ex vivo expansion, and their presumed reduced risk”
• Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma (2006, background): “The latter result is of particular interest given the observed inhibition of pathological cardiac hypertrophy in animals treated with MSCs after myocardial infarction (45, 46) and the well-established link between Akt activation and hypertrophy in cardiac myocytes (47, 48).”