Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

By T. Graham, Qin Yang, M. Blüher, A. Hammarstedt, T. Ciaraldi, R. Henry, C. Wason, A. Oberbach, P. Jansson, U. Smith and 1 more. New England Journal of Medicine, 2006

1,362 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e1b1b95a79d871d22f1420ad6e01139eb4f90e5b

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Citations in the corpus

Adipocytokines in Obesity and Metabolic Disease (2014, positive): “In humans, higher Rbp4 levels are also associated with insulin resistance in obese and diabetic subjects (Graham et al. 2006).”
Chemerin is a novel adipokine associated with obesity and metabolic syndrome. (2007, background): “Elevated levels of RBP4 have been found in mice and humans that are obese and have type 2 diabetes (T2D), and mice engineered to overexpress RBP4 have exhibited insulin resistance (10, 11).”
Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “Chemerin level is positively correlated with BMI, fasting glucose, triacylglycerols, and inflammatory cytokines in obese subjects, and administration of chemerin exacerbates glucose intolerance in obese mice (Ernst et al., 2010).”
Adipocytes as regulators of energy balance and glucose homeostasis (2006, background): “Furthermore, high serum RBP4 levels are associated with insulin resistance in obese humans and those with type 2 diabetes as well as in lean, nondiabetic people with a family history of diabete”
Insulin-sensitive obesity. (2010, result): “Our data support the association between increased omental adipose tissue RBP4 mRNA, circulating RBP4, and whole body insulin resistance (4, 15).”
Adipokines in inflammation and metabolic disease (2011, background): “Studies in human populations have supported this concept: increased serum RBP4 levels were found to associate with features of the metabolic syndrome , including high blood pressure, low levels of high-density lipoprotein, high levels of cholesterol and triglycerides, and increased body mass inde”
Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “(7) Retinol-binding protein 4 which is linked with insulin resistance((41,42)), although its precise role has been debated((43)).”
Mechanisms linking obesity with cardiovascular disease (2006, background): “Several adipokines, such as leptin, adiponectin, TNF-α, IL-6, resistin and the recently discovered visfatin and retinol-binding protein 4 (RBP4”
α-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population (2010, methodology): “Taking a commonly used classification approach [11,21,22,23], the bottom tertile of insulin sensitivity of the entire EGIR-RISC cohort (n = 1293) (i.”
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. (2008, background): “In humans, some studies have shown associations between sRBP-4 and obesity (52), specifically visceral adiposity (53), as well as insulin resistance and type 2 diabetes ( 54 ).”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “RBP4 is elevated in tissue and in the circulation of insulin-resistant humans and rodents (234, 710).”
Adipokines: the missing link between insulin resistance and obesity. (2008, background): “Physical exercise educes RBP-4 levels with improvement of insulin sensitiity [96].”
Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “In humans, RBP4 levels have been shown to be elevated in several groups of insulin-resistant subjects (Graham et al. 2006; Gavi et al. 2007), but not all studies have shown such differences (Janke et al. 2006; Takashima et al. 2006).”