Adipokines in inflammation and metabolic disease
By N. Ouchi, J. Parker, Jesse J. Lugus, K. Walsh. Nature reviews. Immunology, 2011
4,400 citations recorded by the source corpus.
The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/b409ed2312330ef9a123f5eb700e93537ee9c21c
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Citations in the corpus
- Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “Another important function of AT in obesity is to act as an endocrine organ that regulates the production of various hormones and cytokines [45].”
- Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “chronic low-grade inflammation and an activation of the immune system are observed in abdominal obesity and may have a role in the pathogenesis of obesity-related metabolic disorders [2–5].”
- Role of neuroinflammation in neurodegenerative diseases (Review) (2016, neutral): “In obese women, the inflammation state was associated with a higher concentration of pro‑inflam-matory markers including IL-6, CRP and adipokines (42).”
- Adipokines Mediate Inflammation and Insulin Resistance (2013, background): “…mechanisms of obesity-associated T2D are still unclear, however recent studies have shown that low-grade chronic inflammation is an important factor in the pathogenesis of T2D in humans and rodent animal models (Hotamisligil, 2006; Shoelson et al., 2006; Schenk et al., 2008; Ouchi et al., 2011).”
- Pathophysiology of human visceral obesity: an update. (2013, background): “A detailed review of the literature on every adipose tissue-derived adipokine is beyond the scope of this article, and the reader is referred to excellent review papers on this specific topic (21, 407, 447).”
- Inflammation, Oxidative Stress, and Obesity (2011, background): “It is produced mainly by monocytes, lymphocytes, adipose tissue, and muscle [15] and its irregular production participates in the pathogenesis of the obesity-associated metabolic syndrome.”
- Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “cytokines produced by adipose tissue, are able to increase mtROS production [175].”
- Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. (2015, background): “However, in humans with obesity, elevated leptin levels are seen, without any reduction in appetite, due to leptin resistance (152).”
- Body Fat Distribution, Incident Cardiovascular Disease, Cancer, and All-cause Mortality (2013, background): “Adipokines, biologically active molecules secreted from adipose tissue, are key components of these pathways and include inflammatory cytokines, angiogenic factors, lipid metabolites, and extracellular matrix components (15).”