Insulin-sensitive obesity.

By N. Klöting, M. Fasshauer, A. Dietrich, P. Kovacs, M. Schön, Matthias Kern, M. Stumvoll, M. Blüher. American Journal of Physiology. Endocrinology and Metabolism, 2010

840 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/8a1e8e2bc9b6e244a6cc3000584e9f3fafdc79ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. A. Chait
2. Laura J. den Hartigh
3. P. Scherer
4. E. Rosen
5. B. Spiegelman
6. P. Trayhurn
7. Haiming Cao
8. M. Blüher

In Epidemiology

1. B. Spiegelman
2. E. Rosen
3. P. Trayhurn
4. A. Chait
5. Laura J. den Hartigh
6. P. Scherer
7. Haiming Cao
8. G. Hotamışlıgil

In Physiology

1. B. Spiegelman
2. E. Rosen
3. P. Trayhurn
4. P. Scherer
5. A. Chait
6. Laura J. den Hartigh
7. J. Rutkowski
8. M. Czech

Citations in the corpus

• The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, positive): “Several detailed studies have also reported a higher macrophage count in visceral AT of insulin-resistant obese patients compared with lean or insulin-sensitive obese counterparts, an effect that was significantly mitigated following bariatric surgery (10, 114–116).”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “A frequent feature of the MHO population is a lower number of immune cells and a higher proportion of relatively small adipocytes in adipose tissues (77, 114, 115, 117).”
• Insulin action and resistance in obesity and type 2 diabetes (2017, background): “This generates the formation of the phospholipid phosphatidyl 3,4,5-phosphate (PtdIns(3,4,5)P3) from PtdIns(4,5)P2 in the membrane, which facilitates recruitment and interaction between the protein kinases PDK1 and Akt.”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Insulin-sensitiveMHO individuals tend to have lower visceral and intrahepatic fat accumulation than theirMUHO counterparts (203, 400, 401), providing further evidence that these fat depots contribute to insulin resistance.”
• Hypoxia and adipose tissue function and dysfunction in obesity. (2013, background): “In a study on obese humans, higher HIF-1 mRNA levels have been observed in omental, though not subcutaneous, adipose tissue of subjects who were insulin resistant relative to those who were insulin sensitive, suggesting that the tissue of the former group is more hypoxic (102).”
• What We Talk About When We Talk About Fat (2014, positive): “Importantly, however, the humanMHO population tends to have smaller adipocytes than other obese people (Klöting et al., 2010), suggesting that increased expansibility may not account for the improved metabolic profile of these patients.”
• Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis Through Adipose Tissue Crosstalk (2016, background): “Knutson and colleagues showed that leptin prevents the acetylcholine-induced vasodilation mediated by nitric oxide both in vivo and in vitro under obese concentrations of leptin, but not by normal physiological concentrations of leptin (Knudson et al., 2005).”