Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.
By Wenjun Ouyang, M. Löhning, Z. Gao, M. Assenmacher, S. Ranganath, Andreas Radbruch, K. Murphy. Immunity, 2000
804 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/e184d2fac2135932b24f6a62842a78d39b6a0da7
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- Jinfang Zhu
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- K. Murphy
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- M. Afkarian
Citations in the corpus
- Lineage commitment in the immune system: the T helper lymphocyte grows up. (2000, methodology): “GENES & DEVELOPMENT 14:1693–1711 © 2000 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/00 $5.00; www.genesdev.org 1693 ing for IFN and IL-4 or by a powerful new technique that allows detection of surface IFN and IL-4 (Ouyang et al. 2000).”
- Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages (2005, background): “The ability of GATA-3 to promote its own transcription through a cell-intrinsic, positive feedback loop represents a potent mechanism for rapidly stabilizing T H 2 cell developmen”
- Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses (2004, background): “, and ectopic GATA-3 expression in STAT6-deficient cells, stimulated through their T cell receptors, induces the capacity to produce T H 2 cytokine”
- The immunobiology of schistosomiasis (2002, background): “IL-4, which is one of the main products of T H 2 cells, is important in polarizing T H 2 response”
- Differentiation of Effector CD4 T Cell Populations (2010, unknown): “Expression of retrovirally encoded GATA3 in Th1 cells makes these cells competent to produce IL-4 and induces endogenous GATA3 production (53, 55).”
- Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset (2008, background): “An absence of STAT6 precluded the differentiation of 'T H -9' cells, which is in line with the requirement for IL-4 and emphasizes their relationship with the T H 2 program, although T H 2 development can also proceed in a STAT6- and IL-4-independent wa”