The immunobiology of schistosomiasis

By Edward J. Pearce, A. MacDonald. Nature reviews. Immunology, 2002

1,211 citations recorded by the source corpus.

Subfields: Ecology, Parasitology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/f017f4e0ccf686bfdc4a8d68a024bd296b31ba6d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. J. Allen
2. Rick M. Maizels
3. R. Locksley
4. S. V. Van Dyken

In Parasitology

1. TA Wynn
2. J. Allen
3. Rick M. Maizels
4. R. Locksley
5. S. V. Van Dyken

Citations in the corpus

• Eosinophils: changing perspectives in health and disease (2012, background): “Although the eosino phil granule proteins ECP and MBP are toxic to both schisto somules and the larvae of S. mansoni, the manip ulation of eosinophils in mouse models had no signifi cant impact on disease development during S. mansoni infection 56, 57 .”
• Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. (2004, background): “LikeIntroduction wise, infection of mice or humans with Schistosoma mansoni results in a CD4 T cell-dependent Type 2 reInterleukin-4 (IL-4) and IL-13 are closely related cyto- sponse (Pearce and MacDonald, 2002).”
• Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis (2009, background): “The resulting immune response is driven by the production of Th2 cytokines including IL-4, IL-5, IL-13, and IL-21, which contribute to the development of hepatic fibrosis and portal hypertension [2,9,10].”
• Macrophage plasticity and polarization: in vivo veritas. (2012, neutral): “A similar M1-M2 switch has been reported during Schistosoma mansoni and Trypanosoma congolense infection (69).”
• Protective immune mechanisms in helminth infection (2007, neutral): “By contrast, infection with schistosomes elicits an early T H 1-type response, which typically changes to a T H 2-type response following parasite egg depositio”
• Helminth parasites – masters of regulation (2004, background): “Some, like Schistosoma mansoni, have been reviewed recently (22, 23), and within this review, we focus on our own work with nematode models of infection.”