Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation.

By A. Mizoguchi, E. Mizoguchi, H. Takedatsu, R. Blumberg, A. Bhan. Immunity, 2002

1,009 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e09d08969afbac5f4210e046326fa1df8dd3c9dd

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Citations in the corpus

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. (2008, background): “IL-10–produced by B cells can also down-regulate other autoimmune and inflammatory diseases such as collagen-induced arthritis, inflammatory bowel disease, and contact hypersensitivity (17, 41, 42).”
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. (2008, methodology): “according to previously described criteria (28, 37).”
Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “An IL-10-producing regulatory B-cell subset characterized by CD1d upregulation has been shown to be essential for the dampening of the inflammatory response in a model of chronic intestinal inflammation mediated by a Th2 pathway (474).”
Prevention of Arthritis by Interleukin 10–producing B Cells (2003, result): “Thus, our data, together with those recently published describing a role for IL-10–producing B cells in regulating Th2-driven chronic intestinal inflammation, introduce a “regulatory” function for B cells in T cell dependent chronic inflammatory disorders (31).”
B cells regulate autoimmunity by provision of IL-10 (2002, background): “In addition, published data has described a role for IL-10–producing B cells in regulating T H 2-driven chronic intestinal inflammatio”
Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis (2007, result): “This abnormality of B cell cytokine production in patients with MS is of particular interest because the depletion of IL-10 selectively from B cells resulted in more severe phenotypes of EAE and experimental colitis as well as an increased susceptibility to experimental arthritis (16–18).”
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. (2010, background): “Functional analysis of murine Breg cells showed that this population prefer- entially produce IL-10, but can also release transforming growth factor-b (TGF-b), interferon-g (IFN-g), and interleukin-12 (IL-12) (Blair et al., 2009; Evans et al., 2007; Fillatreau et al., 2002; Mizoguchi et al., 2002; S”
The double life of a B-1 cell: self-reactivity selects for protective effector functions (2011, background): “The relationship between the recently identified interleukin-10 (IL-10)-producing regulatory B cell populatio”
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis (2009, background): “Many cell types, including mast cells, epithelial cells and dendritic cells, synthesize IL-10 (refs”
Mucosal immunoglobulins and B cells of Teleost fish (2011, background): “For example, chronic intestinal inflammatory conditions such as experimental colitis prompt the appearance of a B cell subset that produces IL-10 and suppresses progression of intestinal inflammation (Mizoguchi et al., 2002).”
Regulatory B cells: origin, phenotype, and function. (2015, background): “After this, three studies showing that B cells could suppress inflammation by the provision of IL-10 in models of colitis (Mizoguchi et al., 2002), EAE (Fillatreau et al., 2002), and arthritis (Mauri et al., 2003) were published.”