CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
By P. Blair, Lina Yassin Noreña, F. Flores-Borja, D. Rawlings, D. Isenberg, M. Ehrenstein, C. Mauri. Immunity, 2010
1,480 citations recorded by the source corpus.
The immunosuppressive function of regulatory B cells has been shown in several murine models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel disease, and experimental autoimmune encephalomyelitis. Despite interest in these cells, their relevance to the maintenance of peripheral tolerance in humans remains elusive. Here, we demonstrate that human CD19(+)CD24(hi)CD38(hi) B cells possessed regulatory capacity. After CD40 stimulation, CD19(+)CD24(hi)CD38(hi) B cells suppressed the differentiation of T helper 1 cells, partially via the provision of interleukin-10 (IL-10), but not transforming growth factor-beta (TGF-beta), and their suppressive capacity was reversed by the addition of CD80 and CD86 mAbs. In addition, CD19(+)CD24(hi)CD38(hi) SLE B cells isolated from the peripheral blood of systemic lupus erythematosus (SLE) patients were refractory to further CD40 stimulation, produced less IL-10, and lacked the suppressive capacity of their healthy counterparts. Altered cellular function within this compartment may impact effector immune responses in SLE and other autoimmune disorders.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/6ef5292d747751c8e04682b4f281998c8f532d71
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In Immunology
Citations in the corpus
- Genetics and pathogenesis of inflammatory bowel disease (2011, background): “The functional relevance of anti-inflammatory B regulatory (B reg ) cells has been demonstrated in several mouse models of inflammatory diseases, including colitis; B reg cells from patients with SLE also show impaired functio”
- Regulatory B cells: origin, phenotype, and function. (2015, background): “Matsumoto et al. also suggest a developmental link between CD19+CD24hiCD38hi B cells, previously ascribed with a regulatory phenotype (Blair et al., 2010), and IL-10-producing plasmablasts in humans.”
- The double life of a B-1 cell: self-reactivity selects for protective effector functions (2011, background): “However, it is clear that CD5 alone is an insufficient marker for identifying human (or mouse) B-1 cell”
- B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells (2012, background): “The so-called B reg cells identified by some groups (e.g., B10 cells [Yanaba et al., 2008] or TN B cells [Blair et al., 2010]) may simply represent the most active IL-10 producers ex vivo; however, under stimulatory or inflammatory conditions other cells may come into play in vivo (e.g., MZ B…”