B cells regulate autoimmunity by provision of IL-10

By S. Fillatreau, C. Sweenie, M. McGeachy, D. Gray, Stephen Anderton. Nature Immunology, 2002

1,718 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/256547348ae23cc65e298a889cffaf3f24cbb374

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Mauri
2. I. Salinas
3. E. Rosser
4. J. Sunyer
5. Naseem Mushtaq
6. Stephen Anderton
7. D. Gray
8. L. A. Stephens

Citations in the corpus

• Mucosal immunoglobulins and B cells of Teleost fish (2011, background): “It is important to point out that mammalian B cells are known to play an important role in the regulation of inflammation, particularly as regulatory cells that secrete Il-10, a potent anti-inflammatory cytokine (Fillatreau et al., 2008; Fillatreau et al., 2002; Mauri).”
• Regulation of IFN-γ Production by B Effector 1 Cells: Essential Roles for T-bet and the IFN-γ Receptor1 (2005, background): “Importantly, cytokine-producing B cells play a critical protective role in several autoimmune disease models, including inflammatory bowel disease (4), experimental autoimmune encephalomyelitis (6), and collagen-induced arthritis (5).”
• Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis (2007, result): “This abnormality of B cell cytokine production in patients with MS is of particular interest because the depletion of IL-10 selectively from B cells resulted in more severe phenotypes of EAE and experimental colitis as well as an increased susceptibility to experimental arthritis (16–18).”
• Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System1 (2005, background): “vital for recovery from EAE (10), using bone marrow chimeras in”
• CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. (2010, background): “Functional analysis of murine Breg cells showed that this population prefer- entially produce IL-10, but can also release transforming growth factor-b (TGF-b), interferon-g (IFN-g), and interleukin-12 (IL-12) (Blair et al., 2009; Evans et al., 2007; Fillatreau et al., 2002; Mizoguchi et al., 2002; S”
• Prevention of Arthritis by Interleukin 10–producing B Cells (2003, background): “Similarly, chimeras in which only B cells are deficient in CD40, also exhibit the more severe EAE, indicating that CD40 activation of B cells precedes IL-10 production (30).”