Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

By G. Oganesyan, S. Saha, Beichu Guo, Jeannie Q. He, A. Shahangian, B. Zarnegar, Andrea K. Perry, G. Cheng. Nature, 2006

977 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/df6fd52077a20d716ce448666da969902435d032

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Citations in the corpus

TLR3: interferon induction by double-stranded RNA including poly(I:C). (2008, background): “In addition, TRAF3 is involved in the TLR3TICAM-1-mediated IRF-3 activation [59,60].”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Activated TRIF recruits TRAF3, a molecule that is essential for IFN induction in response to TLR stimulation (Hacker et al., 2006; Oganesyan et al., 2006).”
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008, background): “Previously, studies have demonstrated a role for TRAF3 in VISAmediated IRF3 activation (Oganesyan et al., 2006; Saha et al., 2006).”
Regulation and Function of IKK and IKK-Related Kinases (2006, background): “It is also unlikely that TRAF3 regulates the stability of TBK1 and IKKε, because the amounts of TRAF3 protein do not change during TLR signaling and those of TBK1 and IKKε are comparable in wild-type and TRAF3-deficient cells.”
Toll-like receptor function and signaling. (2006, background): “Interestingly, TRAF-3 deficiency also led to similar defective phenotype in TLR7/9 signaling to that of IRF-7– or IRAK-1–deficient mice in terms of selective impairment in type I IFN induction.(53,54) TRAF3 seems to function as a molecular rudder to steer into type I IFN induction.”
MDA5/RIG-I and virus recognition. (2008, background): “IPS-1 was found to associate with TNF-receptor-associated factor (TRAF) 3, an E3 ubiquitin ligase assembling lysine 63-linked polyubiquitin chains, through its C-terminal TRAF domain [28–30].”
RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “TRAF3, which is known to be a E3 ligase for Lys63-linked polyubiquitination, directly interacts with the TRAF-interacting motif (TIM) in the PRR of IPS-1 (71, 72).”
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. (2005, background): “Recent studies have also shown that TRIF and MyD88 can bind to TRAF3, which activates IRFs to induce type I IFNs, but inhibits NF-κB to suppress the induction of proinflammatory cytokines [13, 14 ].”