The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.

By Bo Zhong, Yan Yang, Shu Li, Yan-Yi Wang, Y. Li, Feici Diao, Caoqi Lei, Xiao He, Lu Zhang, P. Tien and 1 more. Immunity, 2008

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization (2009, neutral): “(28) from Shu’s group, and as ‘‘MPYS’’ by Jin et al.”
RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “In this context, mediator of IRF-3 activation (MITA), also known as stimulator of interferon genes (STING), was identified as a critical scaffold protein for IRF-3 activation (86, 87).”
The innate immune DNA sensor cGAS produces a non-canonical cyclic-di-nucleotide that activates human STING (2013, background): “An endoplasmic-reticulum-resident host protein called stimulator of IFN genes (STING; also called TMEM173, MITA, ERIS, and MPYS) was shown to be required for IFN response to cytosolic dsDNA (Ishikawa and Barber, 2008; Ishikawa et al., 2009; Sun et al., 2009; Zhong et al., 2008).”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “Reports of STING on mitochondria and the MAM may be due to the dynamic interactions between these organelles as described above (228, 230).”
The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. (2014, background): “Cytosolic DNA induces type I IFNs through the endoplasmic reticulum membrane protein STING, which subsequently activates the transcription factors NF-kB and IRF3 through the kinases IKK and TBK1, respectively (Ishii et al., 2006; Ishikawa and Barber, 2008; Ishikawa et al., 2009; Stetson and Medzhito”