MDA5/RIG-I and virus recognition.
By O. Takeuchi, Shizuo Akira. Current Opinion in Immunology, 2008
623 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3a109c27b752823fff18a7ad05ba104ccc0a839b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- E. Latz
- Katherine A. Fitzgerald
- V. Hornung
- F. Bauernfeind
- J. Tschopp
- Shizuo Akira
- T. Kanneganti
- M. Lamkanfi
In Molecular Biology
- E. Latz
- Katherine A. Fitzgerald
- T. Fernandes-Alnemri
- V. Hornung
- Xuetao Cao
- E. Alnemri
- J. Tschopp
- T. Kanneganti
Citations in the corpus
- Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 (2009, background): “In the cytoplasm, Nod-like receptors and Rig-I-like helicases respond to defined microbial components gaining access to the cytosol (3).”
- MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK21 (2009, background): “The CARDs associate with IFN- promoter stimulator-1, another CARD containing molecule, which in turn activates Fas-associated death domain (FADD) and TANK binding kinase-1-I B kinase- via TNFRassociated factor (TRAF) 3, resulting in the activation of NF- B, IFN regulatory factor 3 and IFN regulatory”
- TRIM family proteins and their emerging roles in innate immunity (2008, background): “In addition, viral RNAs are recognized by RNA helicases of the retinoic-acid-inducible gene I (RIG-I) signalling pathwa”
- ADAR1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs (2014, background): “RIG-I and MDA-5 share the same pathway to induce IFN production via MAVS (42).”
- RIG-I dependent sensing of poly(dA-dT) via the induction of an RNA polymerase III transcribed RNA intermediate (2009, neutral): “In the cytosol, RIG-I and Mda5 (encoded by Ddx58 and Ifih1 , respectively) discriminate between different classes of RNA viruse”
- Recognition of 5′-triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative strand virus (2009, neutral): “RIG-I is a key sensor of negative strand RNA viruses (Habjan et al., 2008; Plumet et al., 2007; Takeuchi and Akira, 2008).”