RNA recognition and signal transduction by RIG‐I‐like receptors

By Mitsutoshi Yoneyama, T. Fujita. Immunological Reviews, 2009

626 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a8f925ea452a1f1fc3c8def75945ed353834d171

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Citations in the corpus

RIG-I detects viral genomic RNA during negative-strand RNA virus infection. (2010, background): “Sensing of virus presence and cytokine induction via the RIG-I pathway are crucial for successful host defense against infections with RNA viruses (Pichlmair and Reis e Sousa, 2007; Yoneyama and Fujita, 2009).”
Structural and functional insights into pattern recognition by the innate immune receptor RIG-I (2010, background): “Its members include RIG-I, melanoma differentiation–associated gene 5 (MDA5) and laboratory of genetics and physiology-2 (LGP2) receptor”
RNA-based antiviral immunity (2010, background): “Families of well-characterized pattern recognition receptors (PRRs) include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs), which were first cloned in Drosophila melanogaster , plant and mammalian systems, respectivel”
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules (2020, background): “Rig-I and MDA5 contain an RNA helicase domain for binding RNA and a caspase recruitment domain (CARD) for downstream signaling (14).”
STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway (2012, background): “Viral RNA is recognized by membrane-bound Toll-like receptors (TLRs) in the endosome in specialized cells or by retinoic acid–inducible gene I (RIG-I)–like receptors (RLRs) in the cytosol of most, if not all, cells infected by virus (2).”
Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “The RLHs are expressed nearly ubiquitously in hematopoietic and nonimmune cells (Yoneyama and Fujita, 2009), so the absence in CD8a cDCs may be important for the biology of these cells.”
MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response (2011, background): “RLRs comprise RIG-I, MDA5, and LGP2, all of which contain anRNA helicase domain (Yoneyama and Fujita, 2009; Yoneyama et al., 2004).”
Coronavirus infections and immune responses (2020, background): “RIG‐I‐like receptors (RLRs), including the H family members RIG‐I (DDX58), MDA5 (IFIH), and LGP2, primarily recognize nucleic acids of RNA viruses.(12,13) They have a DExD/H‐box RNA helicase structure and a C‐terminal termination structure (CTD), while RIG‐I and MDA5 have an N‐terminal caspase recru”
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “The RLR family consists of three members, RIG-I, Mda5 and LGP2, that detect RNA viruse”