Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

By R. Dolmetsch, U. Pajvani, K. Fife, J. M. Spotts, Michael E. Greenberg. Science, 2001

936 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/df63a0bc55296393321fca51b53f47d61c36d0c5

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala. (2007, neutral): “Moreover, Ca 2þ influx through L-VDCCs has been suggested to trigger long-term memory formation by specifically activating signal transduction pathways involved in transcriptional regulation in the nucleus (Dolmetsch et al., 2001; Deisseroth et al., 2003).”
Voltage-gated calcium channels. (2011, background): “2 channels is required for regulation of transcription in neurons (Bito et al. 1996; Dolmetsch et al. 2001).”
Cell Signaling during Cold, Drought, and Salt Stress Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.000596. (2002, background): “Recent studies with neural cells suggest that calmodulin perceives local Ca2 and activates a MAPK pathway to regulate target gene expression (Dolmetsch et al., 2001), although the connecting point between Ca2 -calmodulin and the MAPK pathway remains unknown.”
Regulation of transcription factors by neuronal activity (2002, neutral): “To identify the protein-interaction domains that are required for signalling to CREB, Dolmetsch et al.43”
Calcium at the Crossroads of Signaling Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.002899. (2002, background): “It has also been shown recently (Dolmetsch et al., 2001) that flux of Ca2 through rat cortical neuron L-type voltage-gated Ca2 channels that possess calmodulin binding domains can lead to nuclear cAMP response element binding protein phosphorylation via a mitogen-activated protein kinase pathway.”
Ras and Rap control AMPA receptor trafficking during synaptic plasticity. (2002, background): “…Ras superfamily have been shown toUniversity of Virginia School of Medicine Charlottesville, Virginia 22908 control important neuronal functions (Dolmetsch et al., 2001; Pak et al., 2001; Wu et al., 2001; Ye et al., 2000) and have significant effects on behavior (Brambilla et al., 1997; Costa…”
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. (2008, background): “Additionally, it has been demonstrated that the calcium-sensing protein calmodulin binds to the intracellular domain of the L-type channel that, upon calcium influx, activates Ras/MAP kinase signaling to initiate gene transcription within the nucleus (Dolmetsch et al., 2001).”
Neuronal voltage-gated calcium channels: structure, function, and dysfunction. (2014, neutral): “2 channels and CREB activation (Dolmetsch et al., 2001).”
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways (2002, background): “These findings seem to indicate that L-type calcium channels have a privileged role in CREB-mediated gene expressio”
The autistic neuron: troubled translation? (2008, background): “Although the resulting enhancement of calcium ion influx may have pleiotropic effects, activation of the ERK pathway and CREB-dependent transcription are major effector mechanisms regulated by L-type VGCCs (Dolmetsch et al., 2001).”