The autistic neuron: troubled translation?

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Mutations causing syndromic autism define an axis of synaptic pathophysiology (2011, background): “Like FXS, (1) TSC is a single-gene disorder with core symptoms of ASD and intellectual disability, (2) the affected gene(s) lie in a signalling pathway that couples cell surface receptors to mRNA translation, (3) there are well validated mouse models of the disease and (4) some mutant phenotypes in ”
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. (2012, background): “…has recently attracted interest as a potential therapeutic in FXS, because it both decreases neuronal excitability via activation of dendritic potassium conductances and directly inhibits the synaptic release of glutamate (and therefore, indirectly, mGluR5 activation) (Kohl and Paulsen 2010).”