Ras and Rap control AMPA receptor trafficking during synaptic plasticity.

By J.Julius Zhu, Yi Qin, Mingming Zhao, L. Van Aelst, R. Malinow. Cell, 2002

814 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/69cab219aeaf5cab451fa8ccad1fadf4b0bc82b9

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Citations in the corpus

Regulation of extrasynaptic signaling by polysialylated NCAM: Impact for synaptic plasticity and cognitive functions (2017, background): “In CA1 neurons, the small GTPase Rap promotes LTD via NMDAR-dependent removal of AMPARs, which requires activation of p38 MAPK (Zhu et al., 2002).”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Additional proteins implicated in AMPAR endocytosis include the AMPAR interacting protein PICK1 (Hanley and Henley, 2005; Kim et al, 2001), the small GTPases Rap1 (Zhu et al, 2002, 2005) and Rab5 (Brown et al, 2005), and a protein termed cpg2 (Cottrell et al, 2004).”
PDZ domain proteins of synapses (2004, background): “and suppresses the Ras–extracellular signal-regulated kinase (ERK) pathway, which regulates synaptic plasticit”
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. (2005, neutral): “between 4 div and 7 div blocks SAP (Figures 2A–2C) and synaptic incorporation of AMPA-Rs (Kolleker et al., 2003; Zhu et al., 2002).”
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. (2006, background): “Small GTPases such as Ras, Rap, and the Rab family of proteins have been shown to be important for AMPAR trafficking (Brown et al., 2005; Park et al., 2004; Zhu et al., 2002), and modulation of GTPase activity by GAPs such as SynGAP have also been implicated in endosomal trafficking of AMPARs (Rumba”
Regulatory mechanisms of AMPA receptors in synaptic plasticity (2007, background): “Actin polymerization, depolymerization and branching are regulated by small G proteins such as Rac, Rho and Ras, which have been implicated in the cytoskeletal dynamics that accompany the developmental, morphological and physiological plasticity of excitatory synapses, including the regulation of ac”
Central sensitization and LTP: do pain and memory share similar mechanisms? (2003, background): “In addition, CaMKII also induces rapid trafficking and incorporation of GluR1containing AMPA receptors into hippocampal synapses via Ras and the subsequent activation of either the ERK or phosphatidylinositol 3-kinase pathways [95, 96 ].”
AMPA receptor trafficking at excitatory synapses. (2003, background): “A number of other kinases have been more tentatively roles or are downstream of CaMKII is not entirely clear, although recent work on MAP kinase (Zhu et al., 2002) linked to LTP.”
Regulation of NMDA Receptor Subunit Expression and Its Implications for LTD, LTP, and Metaplasticity (2008, background): “Ras-GRF1 and RasGAP are likely to affect the induction of plasticity (Zhu et al., 2002).”
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system (2003, methodology): “The fluorescence curve (black) was fitted using equation (3).”