Neuronal voltage-gated calcium channels: structure, function, and dysfunction.

By Brett A. Simms, G. Zamponi. Neuron, 2014

614 citations recorded by the source corpus.

Voltage-gated calcium channels are the primary mediators of depolarization-induced calcium entry into neurons. There is great diversity of calcium channel subtypes due to multiple genes that encode calcium channel α1 subunits, coassembly with a variety of ancillary calcium channel subunits, and alternative splicing. This allows these channels to fulfill highly specialized roles in specific neuronal subtypes and at particular subcellular loci. While calcium channels are of critical importance to brain function, their inappropriate expression or dysfunction gives rise to a variety of neurological disorders, including, pain, epilepsy, migraine, and ataxia. This Review discusses salient aspects of voltage-gated calcium channel function, physiology, and pathophysiology.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96ab4e2369ed50676fbc2c7fd493291001e34e76

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In Cellular and Molecular Neuroscience

1. L. Colucci-D'Amato
2. Floriana Volpicelli
3. Luisa Speranza

Citations in the corpus

• Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020, background): “Activation of L-VGCC and NMDA receptors mediate intracellular Ca2+-signaling and regulate several aspects of brain functions (for review [34,35]).”