Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

By Craig Murdoch, A. Giannoudis, C. Lewis. Blood, 2004

920 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/df59d2c093c8a37e4c3d77e920745c5f8b29d317

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Mayer
2. A. Mantovani
3. Alicia S. Chung
4. N. Ferrara
5. J. Pollard
6. V. Nizet
7. A. Sica
8. John Lee

In Immunology

1. A. Mantovani
2. J. Pollard
3. A. Sica
4. Subhra K. Biswas
5. M. Locati
6. C. Lewis
7. J. Condeelis
8. D. Gabrilovich

In Oncology

1. A. Mantovani
2. J. Pollard
3. A. Sica
4. Subhra K. Biswas
5. M. Locati
6. D. Gabrilovich
7. J. Condeelis
8. C. Lewis

Citations in the corpus

• Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “Other chemokines, such as CCL3, CCL4, CCL5, CCL7, CCL8, CXCL12, and cytokines, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and IL-10, are also reported to promote macrophage recruitment [14, 37–39].”
• Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “Therefore, macrophages constitute promising drug delivery systems for inflammatory diseases such as rheumatoid arthriti”
• Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. (2006, background): “Signals for this macrophage recruitment include hypoxia caused by the tumor’s outgrowing the vascular supply (Murdoch et al., 2004).”
• Macrophages regulate the angiogenic switch in a mouse model of breast cancer. (2006, background): “Numerous studies suggest that hypoxia might be the factor that induces the up-regulation of chemoattractants in tumor cells (33).”
• Hypoxia in cancer: significance and impact on clinical outcome (2007, background): “, angiogenic) cytokines may actually be of high pathophysiological relevance [105, 106].”
• The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “Monocyte recruitment is driven by chemoattractants secreted by both malignant and stromal cells in tumours (reviewed in Ref”
• Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment (2014, background): “Several pieces of evidence have shown that advanced solid tumors exhibit hypoxic areas within the tumor mass and that a high number of TAMs accumulate in the avascular areas of a wide range of human tumors [33].”
• The nature of myeloid-derived suppressor cells in the tumor microenvironment (2016, background): “CCL2 and CCL5 are the main chemokines implicated in monocyte and/or M-MDSC migration to tumors [30,31].”
• Distinct role of macrophages in different tumor microenvironments. (2006, background): “The levels of many of these proteins in human tumors correlate positively with the numbers of TAMs present in those tumors (3).”