The nature of myeloid-derived suppressor cells in the tumor microenvironment

By Vinit Kumar, Sima Patel, E. Tcyganov, D. Gabrilovich. Trends in immunology, 2016

1,793 citations recorded by the source corpus.

Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor microenvironment. The main feature of these cells is their potent immune suppressive activity. MDSC are generated in the bone marrow, and in tumor-bearing hosts, migrate to peripheral lymphoid organs and the tumor to contribute to the formation of the tumor microenvironment. Recent findings have revealed differences in the function and fate of MDSC in the tumor and peripheral lymphoid organs. We review these findings here, and in this context we discuss the current understanding as to the nature of these differences, the underlying mechanisms, and their potential impact on the regulation of tumor progression.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/47cf02c55e753325fea894c432aafe098896ead3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Gabrilovich
2. Zena Werb
3. T. Condamine
4. Je-in Youn
5. E. Tcyganov
6. Hugo Gonzalez
7. C. Hagerling
8. R. DePinho

In Oncology

1. Hugo Gonzalez
2. Garry P. Nolan
3. Zena Werb
4. A. Rustgi
5. D. Gabrilovich
6. R. DePinho
7. C. Hagerling
8. Pengfei Lu

Citations in the corpus

• Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “Naturally, the question arises of how a tumor avoids immune action, such as by T cell exclusion (Joyce and Fearon, 2015) or increased prevalence of certain CTs, including Treg cells, macrophages, and myeloid-derived suppressor cells (Gajewski et al., 2013; Hanahan and Weinberg, 2011; Kumar et al., 2”
• Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “…2012; Snyder et al. 2014; Boger et al. 2017); and (3) induction of the recruitment of TAMs, MDSCs, and Tregs by tumor-derived chemokines such as CCL2, CSF1, CCL5, CCL22, CXCL5, CXCL8, and CXCL12 (Weitzenfeld and Ben-Baruch 2014; Kumar et al. 2016; Mantovani et al. 2017; Tanaka and Sakaguchi 2017).”
• Genetics and biology of prostate cancer (2018, background): “These MDSCs possess potent immunosuppressive activity, play a major role in the suppression of immune responses in cancer through a variety of mechanisms (Gabrilovich and Nagaraj 2009), and have been implicated in the promotion of angiogenesis, tumor cell invasion, and metastases (Yang et al. 2004, ”
• Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients (2016, background): “There is now sufficient evidence demonstrating that tumor MDSCs are more suppressive than cells in PB [reviewed in (28)].”