Macrophages regulate the angiogenic switch in a mouse model of breast cancer.

By Elaine Lin, Jiu-feng Li, Leo Gnatovskiy, Yan Deng, Liyin Zhu, D. Grzesik, H. Qian, Xiaonan Xue, J. Pollard. Cancer Research, 2006

1,066 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/416679f9dc010d1f55f839c649cc0e40a7071736

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. J. Pollard
3. Lisa M. Coussens
4. D. Gabrilovich
5. F. Balkwill
6. Zena Werb
7. A. Sica
8. D. Hanahan

In Molecular Biology

1. Lisa M. Coussens
2. Zena Werb
3. A. Mantovani
4. J. Pollard
5. M. Egeblad
6. D. Hanahan
7. F. Balkwill
8. Subhra K. Biswas

In Oncology

1. J. Pollard
2. A. Mantovani
3. Lisa M. Coussens
4. Zena Werb
5. D. Hanahan
6. R. Weinberg
7. F. Balkwill
8. B. Ruffell

Citations in the corpus

• Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm (2010, background): “M2 macrophages support angiogenesis and lymphangiogenesis by releasing proangiogenic growth factors such as IL-8, VEGFA, VEGFC and EG”
• Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. (2007, methodology): “lower densities of tumor-associated macrophages in Csf1/Csf1/ PyMT mammary tumors (20, 31).”
• The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “Reintroduction of macrophages into these knockout mice led to a significant increase in vascular density and enhanced tumour progressio”
• Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. (2010, background): “TAMs can promote tumor growth by affecting angiogenesis, immune suppression, and invasion and metastasis (2, 3).”
• The tumor microenvironment at a glance (2012, background): “An excellent summary of some of these is given by Joyce and Pollard (Joyce and Pollard, 2009), and some of the commonly used and most informative markers will be detailed below.”
• Microenvironmental regulation of metastasis (2009, neutral): “Bone marrow-derived myeloid cells, including macrophage”
• Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy (2011, background): “Carcinoma cells isolated from MMTVPyMT mice do not express significant levels of CSF1R mRNA (15, 22), indicating that CSF1R blockade in MMTV-PyMT mice influences myeloid biology, as opposed to MECs.”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “In addition to affecting the formation of new tumor vessels, TAMs also stimulate the remodeling of the established vasculature to a more tortuous and leaky form in favor of tumor dissemination [96, 97].”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “, 2006) or genetically restricted the numbers of monocytes/macrophages (Lin et al., 2001; Lin et al., 2006).”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, neutral): “ment in different animal models [19–22].”