Bi-directional protein transport between the ER and Golgi.

By Marcus C. S. Lee, E. Miller, J. Goldberg, L. Orci, R. Schekman. Annual Review of Cell and Developmental Biology, 2004

942 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dec96771bef961bfd94ce332ad3f958e16c27b03

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Citations in the corpus

• Protein quality control in the early secretory pathway (2008, background): “Different mechanisms exist for ER retrieval of membrane proteins (reviewed in Lee et al, 2004).”
• Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (2006, background): “The rescued band C was resistant to processing by endoglycosidase H (Figure S1), a hallmark of transport through the Golgi complex.”
• Inflammasomes and their roles in health and disease. (2012, background): “Unlike conventionally secreted factors, these proteins lack signal peptides to direct them to the translocation apparatus of the classical endoplasmic reticulum (ER)-Golgi complex pathway (Lee et al. 2004, Trombetta & Parodi 2003).”
• Membrane Dynamics in the Early Secretory Pathway (2007, background): “COPII is required for exit of material from the ER and COPI mediates retrograde transport from post-ER membranes (see Lee et al. , 2004 for a comprehensive review).”
• Branching out: mechanisms of dendritic arborization (2010, background): “The three proteins encoded by these genes are crucial regulators of endoplasmic reticulum (ER) to Golgi transport mediated by coat protein complex II vesicle”
• A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee (2006, background): “The latter of course is usually associated with microsomal proteins, albeit there are precedents for them in secreted proteins, where they appear to function in holding the protein on the ER until some signal triggers their release (Ren et al., 2003; Lee et al., 2004; Davis et al., 2006).”
• Mechanisms of regulated unconventional protein secretion (2009, background): “From the ER, proteins are transported to the extracellular space or the plasma membrane through the ER–Golgi secretory pathwa”
• Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide (2006, background): “The trafficking of membrane proteins from the endoplasmic reticulum (ER) to the Golgi apparatus is mediated by transport vesicles, which load the desired set of proteins and deliver them to the correct organelles [1, 2].”
• Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication (2010, background): “The selective recruitment of PI4KIIIb to membranes over COPI will eventually disrupt secretory membrane trafficking and lead to Golgi disassembly by decreasing anterograde transport from the ERGIC and intraGolgi trafficking, both COPI-dependent processes (Lee et al., 2004) (Figure 7B, 2 hr).”