Mechanisms of regulated unconventional protein secretion

By Walter Nickel, C. Rabouille. Nature reviews. Molecular cell biology, 2009

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HIGS: Host-Induced Gene Silencing in the Obligate Biotrophic Fungal Pathogen Blumeria graminis[W][OA] (2010, background): “However, secretion of fungal transcripts into host cells has not been reported so far, in contrast with the secretion of signal-peptide free proteins through a novel pathway independent from the conventional endoplasmic reticulum–Golgi secretory pathway (Nickel and Rabouille, 2009).”
Inflammasomes and their roles in health and disease. (2012, background): “F or p er so na l u se o nl y. secretory lysosomes, or exosomes (Nickel & Rabouille 2009), but whether caspase-1 regulates the trafficking of such membrane-bound particles remains to be determined.”
Understanding the mechanism of IL-1β secretion (2011, background): “mechanism for protein export, it has attained the status of being the ‘conventional’ pathway when compared to the secretion of a handful of proteins that utilise alternative ‘non-conventional’ routes of cellular exit [7].”
Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β (2011, background): “that are conserved at least for a subset of unconventional secretion substrates, in particular, a dependence of their secretion on the Golgi reassembly stacking protein (GRASP) (Nickel and Rabouille, 2009; Duran et al, 2010; Manjithaya et al, 2010).”