Branching out: mechanisms of dendritic arborization

By Y. Jan, L. Jan. Nature Reviews Neuroscience, 2010

670 citations recorded by the source corpus.

Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor–ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Plant Science

View Paper: https://www.semanticscholar.org/paper/2d2a844f722817b876c08fa026b74c95fb4378f1

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Citations in the corpus

• Dendritic Neuron Model With Effective Learning Algorithms for Classification, Approximation, and Prediction (2019, background): “Besides, a slightly morphological difference can lead to the notable functional discrepancy, playing a role in filters to determine the types of signals that single neurons receive and the way used to integrate the signals [27].”