A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee

By C. Claudianos, H. Ranson, Reed M. Johnson, Sunita Biswas, M. Schuler, M. Berenbaum, René Feyereisen, J. Oakeshott. Insect molecular biology (Print), 2006

747 citations recorded by the source corpus.

The honeybee genome has substantially fewer protein coding genes (≈ 11 000 genes) than Drosophila melanogaster (≈ 13 500) and Anopheles gambiae (≈ 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione‐S‐transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10‐fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.

Subfields: Ecology, Evolution, Behavior and Systematics, Genetics, Insect Science

View Paper: https://www.semanticscholar.org/paper/6ec23cd6c6887b5f0521af565e0aca48812565ba

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Citations in the corpus

Nosema ceranae disease of the honey bee (Apis mellifera) (2018, background): “Honey bees have half the P450 genes as some other insects (Claudianos et al. 2006).”
Plant secondary metabolites in nectar: impacts on pollinators and ecological functions (2017, background): “…are responsible for the metabolism of toxins are the cytochrome P450 monooxygenases (P450s), glutathione transferases (GSTs) and carboxylesterases although sequencing of the honeybee genome demonstrated the relative paucity of genes associated with xenobiotic metabolism (Claudianos et al. 2006).”
Uncovering the novel characteristics of Asian honey bee, Apis cerana, by whole genome sequencing (2015, background): “For example, the fatty acid biosynthesis, glutathione metabolism, and cytochrome P450 pathways may be involved in nest-mate recognition and detoxification of pesticides (Additional file 1: Figure S5) [52,53].”
Understanding the Effects of Sublethal Pesticide Exposure on Honey Bees: A Role for Probiotics as Mediators of Environmental Stress (2020, background): “However, honey bees are genetically depauperate in a number of key detoxification genes, with the remainder of relevant genes expressed at low levels (Claudianos et al., 2006).”
Colony Collapse Disorder: A Descriptive Study (2009, background): “Honey bees, as compared to other insects, are notably lacking in detoxification enzymes which provide moderate levels of cross-resistance to pesticides [85].”