The ARF/p53 pathway.
By C. Sherr, J. Weber. Current Opinion in Genetics and Development, 2000
727 citations recorded by the source corpus.
Subfields: Immunology, Oncology, Physiology
View Paper: https://www.semanticscholar.org/paper/debf09e43268340354294df46116349721d4e850
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Citations in the corpus
- Broad targeting of resistance to apoptosis in cancer (2015, background): “The majority of ARF localizes to the nucleolus and nucleoplasm, where it antagonizes the E3 ubiquitin ligase muring double minute 2 (MDM2) to provoke MDM2 degradation, thereby stabilizing p53 protein [58,59].”
- Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization (2002, background): “Furthermore, through inhibiting Mdm2-mediated ubiquitin ligase activity, the p14 arf tumour suppressor can stabilize p53 in vivo in response to oncogene activatio”
- p53 and metabolism (2009, background): “shtml?molecule=arf¯o_process=arf&family_uses=on&complex_uses=on&source_id=5\&what\=graphic\&jpg\=on">ARF , a protein with disparate activities in regulating proliferation, the expression of which is negatively regulated by p53 (Ref”
- ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. (2001, background): “Several cellular proteins, including E2F1, Ras, Myc, -catenin, pRb, and c-Abl, can stabilize p53; in many cases, stabilization is achieved through induction of ARF (for review, see Sharpless and DePinho 1999; Sherr and Weber 2000).”
- Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. (2001, background): “The products of both p53 and p19(Arf) genes have been implicated in some apoptotic pathways (Lowe 1999; Sherr and Weber 2000; Vousden 2000).”
- Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “…the alternative reading frame product of the INK4a/ARF tumor suppressor locus. p19ARF, in turn, can both disable apoptosis and accelerate tumor development in transgenic mice (Attardi and Jacks, 1999;binds and inactivates Mdm2, leading to p53 activation (Lowe and Lin, 2000; Sherr and Weber, 2000).”
- Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. (2005, unknown): “Similarly, induction of the ARF tumor suppressor by oncogenes and other cellular signals leads to increases in p53 protein levels by ARF protein binding to HDM2 and inhibiting HDM2-mediated degradation of p53 (Sherr and Weber, 2000).”
- Apoptosis in development (2000, background): “Second, growth-promoting oncoproteins induce expression of p53 (ref”
- Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence (2003, methodology): “We performed a pulse–chase experiment to examine whether the observed p53 protein induction is secondary to suppression of the p53 degradation pathway by IFN-β, typically the MDM2-mediated pathwa”
- Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses (2003, background): “When induced, p14ARF in humans (p19ARF in mouse) disrupts the interaction between p53 and Mdm2 and sequesters the latter to the nucleolus (Tao and Levine, 1999; Sherr and Weber, 2000).”
- Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “(2010) showed that HSCs have low mitochondrial activity and increased glycolysis, but the majority of our understanding of these pathways comes from studying other cell types.”