Apoptosis A Link between Cancer Genetics and Chemotherapy

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. (2003, background): “Failure to die results in the survival of cells harboring genetic mutations that may become cancerous (Johnstone et al. 2002).”
Awareness and current knowledge of breast cancer (2017, background): “Chemotherapy The process of killing cancer cells by using certain medicines is termed as chemotherapy [202, 203].”
Control of apoptosis by p53 (2003, background): “In addition to its role in suppressing tumorigenesis, p53-dependent apoptosis contributes to chemotherapyinduced cell death (see, for review, Johnstone et al., 2002).”
The Bcl-2 family: roles in cell survival and oncogenesis (2003, background): “As impaired apoptosis plays a central role in the pathogenesis of many diseases, the search is accelerating for novel agents that engage the cell death machinery (Nicholson, 2000; Johnstone et al., 2002; Reed, 2002, 2003).”
The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “Our laboratory discovered that Bcl-2 acts by promoting cell survival rather than by driving cell proliferation and proposed the concept, now widely accepted (Hanahan and Weinberg, 2000; Johnstone et al., 2002), that impairment of apoptosis is a critical step in tumor development (Vaux et al.”