Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

By A. Takaoka, S. Hayakawa, H. Yanai, D. Stoiber, Hideo Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. Honda and 1 more. Nature, 2003

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Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “Finally, the apoptosis-activating gene p53 is also IFN-inducible and can be activated indirectly in response to dsRNA or virus infection to trigger an apoptotic response (Takaoka et al., 2003).”
Cancer despite immunosurveillance: immunoselection and immunosubversion (2006, background): “, can upregulate the p53-mediated response of tumour cell”
Oncolytic viruses: a new class of immunotherapy drugs (2015, background): “Type I IFNs are critical for antiviral and antitumour responses in healthy cells not only because they promote immune responses to clear the virus, but also because they reduce cellular proliferation and activate the proapoptotic protein p53 (REF. 62 ).”
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells (2004, background): “Analogous to most cell types, control-transduced clones express extremely low levels of p53 mRNA (detectable only after 30 cycles of polymerase chain reaction (PCR)-mediated amplification) under basal conditions, because p53 expression is induced by genotoxic stres”