Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.

By M. Takagi, M. Absalon, K. McLure, M. Kastan. Cell, 2005

694 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/bb36eafdbc364c6dfd05232a1bb1d74eaaa6c591

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In Molecular Biology

1. W. Gu
2. C. Brooks
3. C. Kenyon
4. Nataliya Libina
5. Hua Lu
6. Donald M Miller
7. Martin F. Lavin
8. John O. Trent

In Oncology

1. W. Gu
2. C. Brooks
3. Donald M Miller
4. Martin F. Lavin
5. N. Gueven
6. S. Thomas

Citations in the corpus

• Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “One concern was that several RPs have been shown to participate in processes other than translation; for instance the ribosomal protein L26 plays a role in the DNA damage response (Takagi et al., 2005), and L22 and L6 affect transcription by interacting with chromatin (Ni et al., 2006).”
• p53 ubiquitination: Mdm2 and beyond. (2006, background): “Interestingly, DNA damage seems to also stimulate the binding of L26 to the 50 untranslated region of p53 mRNA, causing an increase in the translation of p53 protein and shedding new light on p53 regulation at the translational level (Takagi et al., 2005).”
• The complexity of p53 stabilization and activation (2006, background): “A recent report by Takagi et al.(101) has demonstrated that increased translation of p53 mRNA can also contribute to the induction of p53 protein in irradiated cells.”
• MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “…between the 50TOP motif and miR-10a (Figure 5J). miR-10a Levels Affect Oncogenic Transformation Several studies have demonstrated that increased translation and deregulated translational control mechanisms are hallmarks of cancer (Averous and Proud, 2006; Gazda et al., 2006; Takagi et al., 2005).”
• Discovery and Development of the G-rich Oligonucleotide AS1411 as a Novel Treatment for Cancer (2009, background): “In addition to these papers focused on the cell surface protein, there is mounting evidence that overexpression of nucleolin in general may play a direct role in the process of malignant transformation and progression [132,157-162].”
• How Common are Extra-ribosomal Functions of Ribosomal Proteins? (2009, background): “Recent evidence suggests that S4 can act in a similar way (Torres et al., 2001).”
• Ribosomal proteins: functions beyond the ribosome. (2015, background): “RPL26 is one of the most enchanting RPs because it not only interacts with MDM2, but also associates with p53 mRNA and enhances its translation (Takagi et al., 2005), and this enhancement can be interfered with by oncogenic signals, such as MDM2 (Ofir-Rosenfeld et al., 2008) and TGF-b1 (Lopez-Diaz…”