Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

By C. Rubbi, J. Milner. EMBO Journal, 2003

846 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b882dd763d7c3df6ccc51aa4133d17a0ade487c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Oncology

Citations in the corpus

How Common are Extra-ribosomal Functions of Ribosomal Proteins? (2009, background): “Indeed, it has been suggested that apoptosis is particularly responsive to signals of stress from the nucleolus, the primary result of which is disruption of ribosome synthesis (Rubbi and Milner, 2003).”
How cells coordinate growth and division. (2004, background): “Given its central role in cell growth, it is perhaps not surprising that ribosome biogenesis also regulates cell size, the cell cycle, and responses to stress [78,122,123,155,162,163,165,188].”
Awakening guardian angels: drugging the p53 pathway (2009, background): “Because DRB treatment, nucleotide depletion and DNA damage also lead to nucleolar disruptio”
The Nucleolus under Stress (2010, positive): “Many of the pathways that convert stress signals into a cellular response link the nucleolus to the stabilization and activation of the tumor suppressor and so-called ‘‘guardian of the genome,’’ p53 (Olson, 2004; Pederson and Tsai, 2009; Rubbi and Milner, 2003).”
Nucleophosmin and cancer (2006, background): “There is a functional link between nucleolar integrity and p53 stability, as many of the stimuli that induce cellular stress are able to both affect nucleolar integrity and activate p53 (Ref”
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. (2005, neutral): “DNA damage can disrupt nucleolar integrity and has been reported to cause a release of nucleolin from the nucleolus (Rubbi and Milner, 2003; Daniely et al., 2002).”
Ribosomal proteins: functions beyond the ribosome. (2015, background): “, 2010), and UV (Zatsepina et al., 1989; Rubbi and Milner, 2003) or g-irradiation (Kruhlak et al.”
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. (2004, background): “It has recently been proposed that all stresses that stabilize p53 do so by disrupting the nucleolus (Rubbi and Milner 2003).”