p53 and metabolism

By Karen H. Vousden, K. Ryan. Nature Reviews. Cancer, 2009

1,006 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/86ce03d445665030ed3ee859d548fe8a4f8c0bb9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. C. V. Dang
2. Guido Kroemer
3. L. Galluzzi
4. David M. Sabatini
5. J. Cantor
6. Xiaolu Yang
7. I. Harris
8. Adrian L. Harris

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. David M. Sabatini
4. C. V. Dang
5. Douglas R. Green
6. Timothy R. Peterson
7. J. Cantor
8. Shomit Sengupta

In Oncology

1. Guido Kroemer
2. L. Galluzzi
3. Angelina V. Vaseva
4. Douglas R. Green
5. C. V. Dang
6. Adrian L. Harris
7. David M. Sabatini
8. Carol Prives

Citations in the corpus

• Metabolic control of cell death (2014, background): “Besides regulating cell cycle progression and cell death, p53 controls the expression of several proteins that are directly or indirectly involved in metabolism (107).”
• Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. (2016, background): “The p53 protein has been shown to regulate oxidative phosphorylation as well as glycolysis, which may be related to its ability to suppress tumorigenesis [53].”
• Regulation of cancer cell metabolism (2011, background): “shtml?what=graphic&jpg=on&pathway_id=p53downstreampathway">p53 is best known for its functions in the DNA damage response (DDR) and apoptosis, it is becoming clear that p53 is also an important regulator of metabolis”
• AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan (2011, background): “It is known that p53 is a potent inhibitor of glycolysis whereas it increases aerobic respiration [63].”
• Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species (2010, background): “However, these findings are confounded by other studies showing apparently opposing activities: for example, the presenceof p53-responsive elements in the promoters ofPGM and hexokinase II suggests that p53 can promote at least some steps in glycolysis (3).”
• The first 30 years of p53: growing ever more complex (2009, neutral): “The next decade should see a more detailed description of the roles of the p53 protein in metabolism (see the Review by Vousden and Rya”
• Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress (2010, background): “Central to the coordination of DNA damage responses is the tumor suppressor, p53 (Riley et al., 2008; Vousden and Ryan, 2009).”
• The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. (2017, neutral): “TP53-mediated metabolic changes that occur in cancer cells have been studied for several decades, but our appreciation of the complexity and importance of those changes is only now being realized (Humpton and Vousden, 2016; Parrales and Iwakuma, 2016; Puzio-Kuter, 2011; Vousden and Ryan, 2009).”
• Otto Warburg's contributions to current concepts of cancer metabolism (2011, background): “Although the p53 tumour suppressor has been regarded as the 'guardian of the genome', its function extends to regulation of cell metabolis”
• Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. (2014, background): “In normoxia, ATP generation via glycolysis and OXPHOS seems to be an important mechanism in both cell lines.”
• p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase (2011, background): “Recent studies indicated that p53 also has a role in modulating metabolism including glycolysis and oxidative phosphorylatio”