Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

By T. Wakita, T. Pietschmann, Takanobu Kato, T. Date, M. Miyamoto, Zijiang Zhao, K. Murthy, A. Habermann, H. Kräusslich, M. Mizokami and 2 more. Nature Medicine, 2005

2,936 citations recorded by the source corpus.

Subfields: Epidemiology, Hepatology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/7e6bf1177b3c06876e266acd3a256ac0a141fc9d

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Citations in the corpus

Flaviviridae :T he Viruses and Their Replication (2007, methodology): “culture, but infectivity increased with passage (738,811).”
Unravelling hepatitis C virus replication from genome to function (2005, background): “recently demonstrated that the full-length JFH-1 genome produces infectious particles in cell culture, although the titres were moderate (ref”
The lipid droplet is an important organelle for hepatitis C virus production (2007, methodology): “To elucidate the mechanisms of virus production, we used a HCV strain, JFH1, which can produce infectious viruse”
Mechanism of action of interferon and ribavirin in treatment of hepatitis C (2005, background): “The recent description of a cell-culture system that allows complete HCV replication will probably provide tools to characterize more fully the mechanisms of antiviral activity of IFN and the means to assess new antiviral agent”
Systematic Identification of H274Y Compensatory Mutations in Influenza A Virus Neuraminidase by High-Throughput Screening (2012, methodology): “The technique employed in this study is widely applicable to different fields where reverse-genetics systems exist such as human immunodeficiency virus (38), hepatitis C virus (39), etc.”
Evasion of intracellular host defence by hepatitis C virus (2005, background): “The recent development of cell-culture models of HCV infectio”
Hepatocellular carcinoma pathogenesis: from genes to environment (2006, background): “An important recent advance has been the establishment of a cell-culture model supporting efficient HCV replication and infectious particle productio”
A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity (2014, background): “The establishment of the HCV replicon cell [10,11] and infectious [12–14] systems have paved the way for highthroughput screening of small-molecule inhibitors, and thereby aided the identification of many new classes of antiviral compounds [15,16].”
Hepatitis C Virus Entry Depends on Clathrin-Mediated Endocytosis (2006, methodology): “(56) was linearized at the 3 end of the HCV cDNA by XbaI digestion.”