The lipid droplet is an important organelle for hepatitis C virus production

By Yusuke Miyanari, Kimie Atsuzawa, N. Usuda, Koichi Watashi, Takayuki Hishiki, Margarita Zayas, Ralf Bartenschlager, T. Wakita, M. Hijikata, K. Shimotohno. Nature Cell Biology, 2007

1,303 citations recorded by the source corpus.

Subfields: Biochemistry, Epidemiology, Hepatology

View Paper: https://www.semanticscholar.org/paper/46ac53f6eb2e5933514b219bc93221ddf80c4699

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Erika L. Pearce
2. Edward J. Pearce

In Epidemiology

1. T. Balla
2. Edward J. Pearce
3. Erika L. Pearce
4. Michael D. Buck

In Hepatology

1. T. Balla
2. Ralf Bartenschlager

Citations in the corpus

• Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication (2010, background): “HCV RNA is replicated on remodeled ER membranes whereas structural proteins are located to lipid droplets (Miyanari et al., 2007).”
• SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum (2008, background): “A key premise, however, in the current model proposed for flaviviruses [3,65,66] is the idea that—as in the case of viruses employing spherular replication compartments (see above; [7])—the interior of the vesicles enclosed in the VPs are connected to the cytosol.”
• Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites (2009, background): “At variance with flaviviruses, the membranous web of HCV contains interspersed lipid droplets that play a major role in the assembly of infectious virus particles (Boulant et al., 2007; Miyanari et al., 2007; Shavinskaya et al., 2007).”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “The assembly and secretion process is thought to occur in tight relation with the vLDL biosynthesis machinery, which may explain the possible association of secreted HCV particles with vLDL (André et al., 2005; Nielsen et al., 2006; Miyanari et al., 2007).”
• PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores (2009, background): “This motion may promote assembly of infectious virus by bringing together newly synthesized viral proteins (that accumulate on lipid droplets) and newly replicated viral RNA (present perinuclearly) [186,187].”
• Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development (2014, background): “Perhaps memory T cells, or even other long-lived immune cells, do not store lipid in lipid droplets as a protective mechanism against viruses, which often use these organelles as sites of replication and persistence (Camus et al., 2013; Miyanari et al., 2007).”