Systematic Identification of H274Y Compensatory Mutations in Influenza A Virus Neuraminidase by High-Throughput Screening

By Nicholas C. Wu, Arthur Young, S. Dandekar, Hemani Wijersuriya, Laith Q. Al‐Mawsawi, Ting-Ting Wu, Ren Sun. 2012

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A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity (2014, background): “combined effects of fitness cost and resistance gain of the associated mutations [2,3].”
Measuring the activity of protein variants on a large scale using deep mutational scanning (2014, background): “Other cell-based assays have been developed to select for toxin activity 17 , chaperone activity 18 or drug resistance 19,20 .”
Dissecting enzyme function with microfluidic-based deep mutational scanning (2015, background): “Discussion Deep mutational scanning is a powerful tool for exploring the molecular basis of protein function (7, 15, 25, 26).”