Unravelling hepatitis C virus replication from genome to function

By B. Lindenbach, Charles M. Rice. Nature, 2005

862 citations recorded by the source corpus.

Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this pathogen has met with roadblocks that impeded progress. Its replication was restricted to humans or experimentally infected chimpanzees, and efficient growth of the virus in cell culture failed until very recently. Nevertheless hard-fought progress has been made and the first wave of antiviral drugs is entering clinical trials.

Subfields: Epidemiology, Hepatology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/1dc0f287e8bf07cfb454e24f15f55f641929e6ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Zhijian J. Chen
2. P. Farazi
3. R. DePinho

In Hepatology

1. P. Farazi
2. R. DePinho
3. Shizuo Akira

Citations in the corpus

• Hepatocellular carcinoma pathogenesis: from genes to environment (2006, background): “An important recent advance has been the establishment of a cell-culture model supporting efficient HCV replication and infectious particle productio”
• Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. (2005, background): “HCV infects more than 170 million people worldwide, and approximately 80% of the infected individuals develop persistent infection [ 31 ].”