Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

By F. Kuhnert, C. Davis, Hsiao-Ting Wang, Pauline Chu, Mark Lee, Jenny Yuan, R. Nusse, C. Kuo. Proceedings of the National Academy of Sciences of the United States of America, 2003

670 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dde36e3d6d0a36de2ff1d65b3eb21bbc028ad99e

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Citations in the corpus

Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, background): “Wnt signals are required for the maintenance of active crypt stem cells (Korinek et al., 1998; Kuhnert et al., 2004; Pinto et al., 2003).”
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011, methodology): “injection of adenovirus encoding either the Wnt agonist Rspo1 or antagonist Dkk1 results in hepatic infection and transduction, secretion of the recombinant factor into the systemic circulation, and leads to profound histological changes in the intestinal epithelium within 5 d after infection (14).”
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength (2014, positive): “2; Pinto et al. 2003; Kuhnert et al. 2004), Dkk1 being a secreted Wnt antagonist (Glinka et al. 1998).”
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, background): “, 2007) as well as transgenic expression of the secreted Dickkopf-1 Wnt inhibitor (Pinto et al., 2003; Kuhnert et al., 2004) leads to disappearance of proliferative crypts in adult mice.”
Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “First, removal of Tcf4, -catenin, or overexpression of the Wnt inhibitor Dkk-1 results in a severe loss of proliferative epithelial cells in both the fetal and adult intestine (Korinek et al. 1998; Pinto et al. 2003; Ireland et al. 2004; Kuhnert et al. 2004).”
Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis (2009, methodology): “After systemic injection, adenoviruses are taken up by liver cells, which then express the molecules encoded by the viruses (16).”
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast (2011, background): “First, we found that secretion of the canonical Wnt signaling antagonist Dickkopf-1 (DKK1) (Kuhnert et al., 2004) was downregulated in both HTwist and MSP cells (Figure 2G).”
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche (2009, background): “Extracellular Wnt signals are absolutely required within the ISC niche, as deduced from the rapid ablation of proliferation and secondary loss of differentiation observed with the secreted Wnt inhibitor Dickkopf-1 (Dkk1”
Wnt signaling: is the party in the nucleus? (2006, background): “1394 GENES & DEVELOPMENT 20:1394–1404 © 2006 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/06; www.genesdev.org components results in depletion of intestinal crypt stem cells and loss of proliferative epithelial cells (Pinto et al. 2003; Kuhnert et al. 2004).”