The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
By W. de Lau, W. Peng, P. Gros, Hans Clevers. Genes & Development, 2014
620 citations recorded by the source corpus.
Adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists. This review by de Lau et al. focuses on the complex physical and functional interactions of three recently discovered protein families that control stem cell activity by regulating surface expression of Wnt receptors: Lgr5 and its homologs, the E3 ligases Rnf43 and Znrf3, and the secreted R-spondin ligands.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/9691df35f2bbb9299f967abb1e1937bd65f6a602
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In Molecular Biology
- Hans Clevers
- R. Nusse
- Alexander van Oudenaarden
- R. Vries
- Gad Getz
- Matthew Meyerson
- Chip Stewart
- J. Sáez-Rodríguez
Citations in the corpus
- Prospective derivation of a Living Organoid Biobank of colorectal cancer patients (2015, background): “RNF43 encodes a negative regulator of the Wnt pathway, which serves to remove the Wnt receptor FZ in a negative feedback loop (Hao et al., 2012; Koo et al., 2012, de Lau et al., 2014).”
- Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “A model, strengthened by X-ray crystallography (de Lau et al., 2014), was then formulated in which R-spondin’s high-affinity interaction with Lgr5 through its Furin-2 repeat, allows the other Furin repeat in R-spondin to interact with Rnf43/Znrf3.”