Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis

By R. Daneman, D. Agalliu, Lu Zhou, F. Kuhnert, C. Kuo, B. Barres. Proceedings of the National Academy of Sciences of the United States of America, 2009

671 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/860afeeba6288323e84fbbf6496f028107a92bc6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Amanda F. Levy
2. Mao Ye
3. Peter C. Searson
4. Jeffrey D. Rothstein
5. D. Bergles
6. Andrew D. Wong

In Molecular Biology

1. A. Prat
2. Peter C. Searson
3. Carola Förster
4. R. Daneman

Citations in the corpus

• In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use (2016, background): “developmentally relevant in vivo canonical Wnt signaling events between neural progenitor cells and endothelial cells.(118,270,271) Similarly, the cord blood-derived endothelial cells are regulated by addition of Wnt3a or Wnt7a, resulting in increased TEER compared to un-stimulated monocultures.”
• The blood-brain barrier: an engineering perspective (2013, background): “Studies in mice have shown that perictyes are recruited to nascent capillaries during development (Daneman et al., 2009, 2010) and are key for development of the BBB and regulating transport across the BBB (Armulik et al., 2005, 2010; Daneman et al., 2009, 2010; Kim et al., 2009) Indeed, pericyte…”
• Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation (2012, positive): “Moreover, in vivo inactivation of Wnt factors (Wnt7a and Wnt7b) [100], Fz4 receptor [101] or injection of a soluble inhibitor of the Wnt/ Frizzled receptor interaction [102] lead to major vascular defects in the CNS (interestingly, not in non-neuronal tissues) and to BBB breakdown, clearly demonstra”
• The blood–brain barrier in health and disease: Important unanswered questions (2020, background): “Different Wnt ligands and receptor complexes have been shown to promote BBB formation in different regions of the CNS (Daneman et al., 2009; Wang et al., 2012, 2018; Zhou et al., 2014); however, it is not clear whether this induces regional heterogeneity or is merely a remnant of dorsal–ventral and…”
• The blood-brain barrier. (2015, background): “…progenitors, a loss of capillary beds, Cite this article as Cold Spring Harb Perspect Biol 2015;7:a020412 9 and the formation of hemorrhagic vascular malformations, which together suggest that Wnt is a migration signal driving vessels into the CNS (Stenman et al. 2008; Daneman et al. 2009).”