Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

By Laurens G. van der Flier, M. V. van Gijn, P. Hatzis, P. Kujala, A. Haegebarth, D. Stange, H. Begthel, Maaike van den Born, V. Guryev, I. Oving and 5 more. Cell, 2009

723 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/657bbbb7893c11d56c3dca5c887169c3d6ad8f7b

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In Genetics

1. Hans Clevers
2. R. Weinberg
3. E. Batlle
4. Hugo J. G. Snippert
5. Stephen R. Quake
6. M. van de Wetering
7. Alexander van Oudenaarden
8. Shalev Itzkovitz

In Molecular Biology

1. R. Weinberg
2. Hans Clevers
3. E. Batlle
4. M. van de Wetering
5. Hugo J. G. Snippert
6. Stephen R. Quake
7. T. Shibue
8. Piero Dalerba

In Oncology

1. R. Weinberg
2. Hans Clevers
3. E. Batlle
4. Hugo J. G. Snippert
5. Piero Dalerba
6. Dalong Qian
7. Y. Shimono
8. T. Shibue

Citations in the corpus

• Single-cell dissection of transcriptional heterogeneity in human colon tumors (2011, background): “, (ii) a cell compartment characterized by the co-expression of genes associated with immature cells as well as genes known to be expressed by enterocytes ( OLFM4 + , CA2 high ) and (iii) a cell compartment whose gene-expression profile mirrors that of a stem and/or progenitor cell compartment in”
• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011, background): “By 5 d after infection, Ad Rspo1-Fc markedly expanded Lgr5-eGFP cells, and expression of the surrogate marker Olfm4 (7), which was not seen with a control adenovirus encoding IgG2α Fc (Ad Fc) (Fig.”
• The intestinal crypt, a prototype stem cell compartment. (2013, background): “Thus, the transcription factor Ascl2 was identified as a master regulator of the Lgr5 stem cell (van der Flier et al., 2009b).”
• Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012, positive): “…of SCs. Supporting this notion, Sox9 has been shown by others to be expressed in SCs or progenitor cells in multiple epithelial tissues, including the skin, intestine, liver, and pancreas (Furuyama et al., 2011; Kopp et al., 2011; Nowak et al., 2008; van der Flier et al., 2009; Vidal et al., 2005).”
• The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. (2011, background): “Also, purified cd133 + tumor-initiating cells can be expanded in vitro as an undifferentiated population that upon xenotransplantation generates tumors that contain differentiated-like cells (Vermeulen et al., 2008).”