Wnt signaling in the intestinal epithelium: from endoderm to cancer.

By A. Gregorieff, Hans Clevers. Genes & Development, 2005

721 citations recorded by the source corpus.

The Wnt pathway controls cell fate during embryonic development. It also persists as a key regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational deregulation of the Wnt cascade is closely associated with malignant transformation. The intestinal epithelium represents the best-understood example for the closely linked roles of Wnt signaling in homeostatic self-renewal and malignant transformation. In this review, we outline current understanding of the physiological role of Wnt signaling in intestinal biology. From this perspective, we then describe how mutational subversion of the Wnt cascade leads to colorectal cancer.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eea53eef66dbab6643109783606f842a6dcdf0b4

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Citations in the corpus

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction? (2006, background): “These mutations have been thought to be solely responsible for the initial progression of almost all cases of human colorectal cance”
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, background): “Transgenic animals were analyzed at P14 when they were still relatively healthy, yet had already replaced their postnatal intervillus pockets by adult-type crypts (Gregorieff and Clevers, 2005).”
Wnt signaling: is the party in the nucleus? (2006, background): “To better understand the complex roles of Wnt signaling in development, organogenesis, and cancer, we refer the reader to several excellent recent reviews (Bienz and Hamada 2004; Moon et al. 2004; Nelson and Nusse 2004; Bienz 2005; Gregorieff and Clevers 2005; Kohn and Moon 2005; Radtke and Clevers ”
Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation. (2006, background): “The intestinal epithelium is a continually renewing tissue that reuses developmental programs throughout adult life (Gregorieff and Clevers, 2005), thus microbial regulation of these programs may have long-term effects on digestive tract health.”
Hepatocellular carcinoma pathogenesis: from genes to environment (2006, background): “This transcription factor complex transactivates a host of target genes governing cancer-relevant processes, including MYC , cyclin D1 , COX2 , and matrix metalloproteinase 7 ( MMP7”
DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling (2009, background): “Together, these results implicate DISC1 in GSK3b/b-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders.”
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, background): “More sophisticated models that do incorporate feedback have been discussed; for instance, negative cross-talk between BMP signaling in the villi and WNT signaling in the crypts might allow true homeostasis (Crosnier et al., 2006; Gregorieff and Clevers, 2005).”